VP, DM1 Commercial Asset Lead

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook. Role Summary: The VP, DM1 Commercial Asset Lead (CAL) is a passionate driver of the value of Dyne’s DM1 commercial asset with a global perspective, bringing adaptable leadership to develop and implement commercialization strategies that maximize reach and value creation within the neuromuscular portfolio. This mandate includes market analysis, competitive positioning, launch readiness and execution, and input into lifecycle management to support long-term success in bringing the asset to patients globally. The CAL is a highly visible leadership role and, as a key member of the Program Team, works cross-functionally to influence and help shape Program strategy. The CAL leads the definition of commercialization strategy, strategic imperatives, critical success factors, executional priorities, and global launch planning in close partnership with affiliate launch teams. This role balances a forward-looking orientation toward broad global access for patients with a pragmatic approach to planning, risk mitigation, and execution. The CAL collaborates with Program Team members, functional leads, and affiliate teams to achieve a differentiated product profile, competitive label, broad reimbursement, and successful global launches, starting with the U.S. As a member of the Program Team, the CAL is responsible for advancing commercialization readiness and works in strong partnership with the Program Lead, Head of Commercialization, functional leaders, and affiliate launch teams. This role is based onsite in Waltham, MA. Primary Responsibilities Include: Global Commercial Strategy & Asset Leadership Define global asset commercialization strategy and plan to achieve milestones and timelines for successful launches Shape competitive positioning, differentiation strategy, and overall value proposition Provide commercialization input into program strategy, including label and access considerations Establish strategic imperatives, critical success factors, and execution priorities Launch Readiness & Market Planning Lead global launch planning and readiness across key markets, starting with the U.S. Partner with cross-functional teams (medical, regulatory, supply, marketing, digital, data) to prepare for launch execution Collaborate with affiliate teams and external partners to support reimbursement and access readiness Drive continuous improvement and learning across markets Cross-Functional Leadership & Program Integration Serve as a key member of the Program Team and lead the DM1 Commercial Sub-Team Ensure alignment across commercialization pillars (product profile, access, launch planning) Facilitate cross-functional decision-making and drive timely outcomes Build strong partnerships across functions and maintain clear communication with leadership External Engagement & Stakeholder Management Build a credible and visible presence within the DM1 community, including KOLs, patient advocacy groups, and care teams Maintain awareness of competitive landscape and evolving market dynamics Support preparation and presentation of commercialization materials for senior leadership and Board discussions Participate in business development activities, including opportunity evaluation and due diligence, as needed Education and Skills Requirements: Bachelor’s degree in a relevant scientific, medical, or business discipline required; advanced degree strongly preferred Minimum of 20 years of experience in the biopharmaceutical industry 15+ years of commercialization and cross-functional leadership experience Extensive experience leading global product launches, including a minimum of 3 launches Rare disease experience strongly preferred; neuromuscular experience highly advantageous Proven track record of delivering on business objectives in fast-paced, high-stakes environments Proven ability to steer assets from late-stage development through approval and launch Experience influencing global and U.S. market access and reimbursement readiness Demonstrated success developing global commercialization strategies Experience collaborating across clinical, medical, regulatory, supply, and commercial functions Ability to synthesize complex data to guide strategy Strong cross-functional leadership and stakeholder influence Proven ability to inspire and mobilize high-performing teams Exceptional communication and stakeholder engagement skills Ability to build strong external relationships (KOLs, advocacy, payers, regulators) Comfortable leading through ambiguity and change High integrity and strong patient-centric mindset Strong sense of urgency and ability to prioritize effectively #LI-Onsite MA Pay Range $272,000—$340,000 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.