Vice President, Supply Chain

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future. 4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY The Vice President, Supply Chain is responsible for the end-to-end strategy, execution, and governance of global supply operations across all phases of development, including global clinical supply and commercial launch preparation. This role ensures uninterrupted, compliant, and cost-effective supply of investigational and commercial products, comparators, ancillaries, and open-label therapies to support global clinical trials and commercial launch. This leader will build and scale a best-in-class supply organization, partner closely with Clinical Operations, CMC, Regulatory, Quality, Commercial and external vendors, and provide senior level oversight of supply risk, forecasting, and readiness in support of critical development and registration milestones. MAJOR DUTIES & RESPONSIBILITIES: Strategic Leadership Define and execute the global supply strategy across early- and late-stage programs, including Phase 1–3, commercial launch, and post-approval commitments Serve as the enterprise leader for clinical trial supply governance, risk management, and scenario planning Build a commercial-ready supply chain organization to support product launch Provide senior-level input into development timelines, enrollment strategies, and global expansion plans based on supply feasibility Anticipate and proactively mitigate supply risks (manufacturing capacity, comparator shortages, import/export constraints, depot limitations, based on deep experience with global supply chain) Drive BLA-enabling supply chain activities, including shipping validation, planning for commercial labeling processes, and temperature monitoring strategies. Provide support for combination device strategy (such as co-packaging with needles and syringes, pre-filled syringes, and other approaches, including device compatibility strategies), and launch forecasting and planning. Lead building of commercial ready supply chain capabilities in partnership with commercial team, including forecasting, vendor selection, and system readiness. Operational Oversight Oversee end-to-end clinical supply execution, including: Demand forecasting and supply planning Packaging, labeling, and distribution Depot strategy and inventory management Open-label and rescue medication sourcing (e.g., comparator biologics) Management of drug product inventory, including production needs, regulatory timing, and QP approval for introduction of new lots Balance supply needs with financial ones, including management of cost, expiration dating, potential delays, and clinical enrollment projections. Ensure timely and compliant supply to global investigational sites while supporting enrollment acceleration and protocol amendments Lead contingency planning for constrained supply scenarios and high-enrolling sites Build Commercial Supply chain organization, including: Demand Forecasting Commercial Pack and Label for US and global launch 3PL selection and Depot forecasting Cold-chain network for worldwide shipping Shipping validation Serialization Selection and implementation of ERP inventory management systems Author appropriate BLA sections Vendor & Partner Management Select, manage, and govern global supply vendors (CMOs, depots, couriers, comparator sourcing partners), and work closely with global CROs (pack and label vendors, clinical trial vendors, commercial vendors) to ensure smooth uptake/launch in new countries Establish performance metrics, KPIs, and escalation pathways to ensure vendor accountability Negotiate contracts and manage budgets for clinical supply and commercial launch operations Drive continuous improvement and cost optimization across the supply network Cross-Functional Leadership Partner closely with: Clinical Operations (site activation, enrollment strategy) CMC / Technical Operations (manufacturing timelines, release) Quality Assurance (GxP compliance, audits, inspections) Regulatory Affairs (import/export, labeling, country requirements) Commercial team (BLA and launch planning, commercial supply) IT (commercial system readiness) Act as a strategic advisor to program teams and executive leadership on supply-related decision-making Quality, Compliance & Inspection Readiness Ensure full compliance with GMP, GDP, ICH, FDA, EMA, and global regulatory requirements Maintain inspection-ready systems, documentation, and processes Lead responses to regulatory inspections, audits, and findings related to supply chain Team Building & Leadership Build, mentor, and lead a high-performing global supply chain organization Establish scalable processes, SOPs, and operating models appropriate for company growth, including selection and introduction of appropriate software tools Foster a culture of accountability, transparency, and proactive problem-solving Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time QUALIFICATIONS: Education: Bachelor’s degree in Life Sciences, Pharmacy, Engineering, or related field (advanced degree preferred) Experience: 18+ years of experience in Pharmaceutical/Biotech supply chain, 7+ years of senior leadership experience managing global teams and vendors Demonstrated experience managing clinical supply for global Phase 3 clinical trials Demonstrated experience transitioning supply chain organizations from clinical to commercial launch ideally in a biotech/small company environment, including experience encompassing the successful launch of a commercialized product, ideally in a large therapeutic market. Proven ability to operate effectively in high-complexity, fast-paced biotech environments Preferred: Experience supporting biologic, gene therapy, or specialty ophthalmology products Strong background in managing constrained or high-risk supply scenarios MBA or advanced scientific degree a plus Other Qualifications/Skills: Executive presence and strategic thinking Strong cross-functional influence without direct authority Exceptional problem-solving and risk-mitigation skills Data-driven decision making and forecasting expertise Ability to balance speed, quality, and compliance Clear, confident communicator with internal and external stakeholders Travel: less than 5% Physical Requirements and Working Conditions: Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word. Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met. Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work). Base salary compensation range: $308,000 - $354,000 Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. 4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities