Senior Research Associate, Analytical Development

Using living cells to treat – and sometimes even cure – cancer is one of the most dramatic advances in modern medicine. Patients with hematologic malignancies have been successfully treated with cell therapies. However, these profound results have not yet been achieved in patients with solid tumors, representing approximately 90% of all cancers. And for patients with hematologic malignancies, there is a need for next-generation cell therapies that can deliver increased response rates and longer duration of response. We are a clinical-stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with solid tumors or hematologic malignancies. Lyell’s product candidates are enhanced with novel technology designed to generate T cells that resist exhaustion and have qualities of durable stemness in order to drive durable tumor cytotoxicity and achieve consistent and long-lasting clinical response. We were founded by cell therapy pioneers whose decades of research elevated the broader understanding of T-cell biology and its interaction with cancer. In our quest to advance next-generation CAR T-cell therapies, we have built a fully integrated company capable of discovering new technologies, translating science into therapies, manufacturing cell therapy products, and clinically evaluating them in patients. Our culture is based on Science, Respect, Collaboration, and Courage and reflects who we are, the environment we create, and our mission's urgency. POSITION SUMMARY: The candidate works collaboratively on design and execution of assays, where data analysis requires an in-depth evaluation of variable factors. Exercises independent judgment in selecting methods, techniques and evaluation criteria for obtaining results. Begins to take on a central role in developing timelines for specific objectives within their projects. Responsible for keeping abreast of current publications relative to methods, techniques, and developments within the area of research, and will report on how new external learnings can be integrated into current projects. Networks with colleagues outside their own area of expertise. Responsible for carrying out a variety of experiments within the area of focus. KEY ROLE AND RESPONSIBILITIES: Design, execute and analyze experiments independently Generation, maintenance and review of electronic lab notebook reports Collaborate internally to Interpret, interrogate and troubleshoot data as well as troubleshoot analytical methods and equipment Responsible for the completion of research, experiments and assignments that have an impact on functional goals REQUIRED EXPERIENCE: BS. in biotechnology, molecular biology, microbiology, immunology, oncology or related field Minimum of 3 years' experience with cell-based assays – specifically cytokine release and cytotoxicity assays Excellent sterile and cell culture technique working with human cells Experience with one or more cell-based assay platforms Ella, MSD, xCelligence, Incucyte Minimum of 1 year experience in 6+ color flow cytometry Ability to analyze data and interpret results with minimal supervisor guidance PREFERRED EXPERIENCE: Experience with instruments MACSQuant or Lyric Experience in data production and reporting for IND-enabling studies Experience with CAR T cell data and analysis Exposure to molecular biology protocols (i.e. VCN) KNOWLEDGE, SKILLS AND ABILITIES: Basic Knowledge of human immunology Highly proficient in using Microsoft Office (Word, Excel, PowerPoint) and data analysis software packages (Prism, Flow Jo, Spotfire, Geneious, etc) Effectively communicate and discuss results with other scientists on the team Ability to work in a matrixed environment General comfort in learning to work with new software and automated lab equipment Lyell offers its employees a range of compensation and benefits. To assist you with your decision to apply for this role, the following decision to apply for this role, the following information and links to our site highlight our competitive market position and support to our employees and their dependents. The salary range for this position is $95,000 to $118,000, annually, with the opportunity to earn an annual bonus. The salary range is an estimate, and the actual salary may vary based on Lyell’s compensation practices and an applicant’s qualifications and experience. Employees are also eligible to participate in Lyell’s Equity Incentive Plan. Our Employee Benefits program is extensive and includes subsidized medical, dental and vision plans from your first day of employment, FSA, Company provided Life and AD&D Insurance as well as STD and LTD Insurance, ESPP, a 401(k) Plan with Company match, mass transit commuter benefits, cell phone reimbursement and a range of supplemental benefits that you may choose to elect. Our paid time-off benefits currently include Flex Time off, sick leave, 8 observed holidays as well as a floating holiday. We also have a winter office shutdown. At Lyell, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse and inclusive culture for all employees. Lyell is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws. We’ve learned from experience that some of the best people don’t always match our requirements perfectly - if you’re interested and think you could fit, please don’t hesitate to apply.