Principal Scientist, Immunology

Nilo Therapeutics is an early-stage biotech company developing groundbreaking therapies for autoimmune and inflammatory diseases. Our experienced team brings together diverse interdisciplinary expertise to modulate immune responses via activation of neural circuits. United by our passion for discovering and translating novel biology, we are dedicated to advancing human health through transformative science. We are backed by The Column Group, Lux, and DCVC Bio. Position We are seeking a highly motivated, on-site Principal Scientist to join our Therapeutics Biology team. This role will be part of a team focused on foundational discovery biology, evaluating the therapeutic potential of our neuro-immune platform and validating targets at the bench across a broad range of autoimmune diseases. Ideal candidates will use their scientific acumen and collaborative approach to partner across the interdisciplinary Nilo team on all aspects of the drug discovery process. This is an exciting opportunity to lead innovative research projects and make significant contributions to our mission of advancing therapeutic solutions. At Nilo Therapeutics, we are a dynamic start-up at the forefront of biotech innovation, driven to discover novel biology and develop new drugs. We seek team members who are inspired by our mission and thrive in a collaborative, rigorous, and entrepreneurial environment. Ideal candidates are self-motivated, proactive problem solvers, excited to build and grow the company alongside a world-class team. If you are comfortable with managing multiple projects and possess a resourceful, can-do attitude, we would love to hear from you. Join us and contribute to our mission of advancing innovative therapies at the intersection of neuroscience and immunology. What you’ll do: Independently design and conduct both in vitro and in vivo models of inflammation Develop acute and chronic experiments in rodents to evaluate targets using inflammatory disease models Utilize primary cell culture, multi-color flow cytometry, ELISA, basic molecular biology and immune assays to probe the neuro-immune axis Perform H&E / immunofluorescence staining and confocal microscopy Stay up to date with emerging scientific literature and contribute to the strategic vision of the company. Collaborate cross-functionally with experts in Neuroscience, Bioinformatics, Drug Discovery and CROs to advance target identification and validation Independently prepare data and present to the team Work to improve existing animal protocols and implement solutions / troubleshoot as needed Key Qualifications: Ph.D. in Immunology, Biology, or a related discipline 5-8 years of biotech or pharma industry experience Strong background in immunological assays, both in vitro, ex vivo, and in vivo Extensive hands-on experience working with disease models in rodents Hands-on experience with multi-color flow cytometry, confocal microscopy, primary cell culture, ELISA, and basic molecular biology techniques Excellent organizational and communication skills, with the ability to manage multiple projects and deadlines. Flexibility to learn new methods and skills for changing research priorities Ability to keep detailed and organized records of experimental protocols and results Ability to work independently and collaborate as member of a research team Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines Proven ability to work collaboratively in a multidisciplinary team environment and motivated to make significant contributions for the growth of a high-paced start-up. A passion for high-quality, translational science and a desire to discover novel biology and new drugs We offer a competitive compensation package that includes a range of benefits designed to support the well-being and professional growth of our team members. Nilo Therapeutics is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment. We are committed to creating a diverse and inclusive environment and encourage individuals from all backgrounds to apply.