Director, Global Health Economics & Outcomes Research (HEOR)

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook. Role Summary: We are seeking a Director, Global HEOR, to lead the strategy and execution of how we define, substantiate, and communicate the value of one or more medicines approaching commercialization. This role is responsible for ensuring that, from clinical development through real-world evidence generation and payer engagement, we are making the strongest and best-supported arguments to secure access to our medicines. Accordingly, the Director, Global HEOR, helps shape development plans, evidence strategies, and value narratives so that they align with how payers and health technology assessment (HTA) bodies make decisions, balancing analytical rigor with a clear focus on what is relevant for decision-making. This is a highly cross-functional, hands-on role for someone who combines deep analytical thinking with sound judgment, intellectual curiosity with pragmatism, and a strong orientation toward results. The role directly influences how our medicines are developed, positioned, and ultimately accessed by patients worldwide. Success in this role requires continually asking not just “Is this analysis methodologically defensible?” but “Does this help us make a better case for access, and if not, what would?” This role is based in Waltham, MA. Primary Responsibilities Include: Informing development strategies from HEOR / market access perspective Represent the HEOR and market access perspective in internal clinical development and regulatory forums Provide critical input into clinical development plans, including protocol design, endpoint selection, and other aspects of clinical trial evidence generation, to ensure alignment with future payer and HTA expectations Communication of value to payers and HTA bodies Lead development of AMCP dossiers for US payers Lead development of cost-effectiveness models for NICE and other HTA bodies requiring formal cost-effectiveness analyses Serve as a core team member for HTA submissions outside the US, with responsibility for shaping and stress-testing value narratives included in pricing and reimbursement dossiers and interpreting and recommending evidence to support such narratives, in a way that optimizes both credibility and relevance for payer decision-making Make substantial contributions to other payer communication materials (e.g., Medical Value Liaison slide decks) and launch readiness activities as needed Leading real-world evidence strategy and execution of real-world analyses Lead planning of real-world evidence generation activities to address evidence gaps as needed for informing decision-making by payers, HTA bodies, and clinicians Oversee execution of real-world data analyses, ensuring analytical rigor and fitness for purpose Interpret and translate results from real-world analyses into peer-reviewed publications and other external communications intended to meaningfully inform clinical practice and payer/HTA decision-making Education and Skills Requirements: Bachelor’s degree or equivalent experience in a relevant field such as economics, public health, epidemiology, biostatistics, health policy, life sciences, or a related discipline. Advanced degrees (Master’s, PhD, PharmD, MD) are welcome but not required. 10+ years of progressive experience in HEOR, health analytics, value demonstration, market access, or a closely related quantitative or scientific field. Demonstrated success leading complex evidence‑generation, modeling, or analytical programs within biopharma, healthcare consulting, payer organizations, or academic research environments. Experience influencing senior leaders and driving strategic decisions through evidence and structured analysis. We are looking for candidates who demonstrate the following skills and qualities: Analytical ability: Strong reasoning and structured problem‑solving capabilities, with curiosity, persistence, and creativity to tackle complex, open‑ended problems. Sophisticated understanding of evidence: Clear judgment about what different analytical methodologies can and cannot tell you, and what makes an analysis more or less robust. Understanding of value frameworks: Familiarity with decision‑making frameworks that inform how medicines are valued, priced, and reimbursed. Strong mathematical intuition: Deep understanding of how numbers work, how models behave, and how assumptions propagate through analyses. Critical evaluation of scientific literature: Ability to read, interpret, and rigorously critique medical, scientific, and health economics publications. Biological and clinical literacy: Sufficient grounding in biology and clinical science to engage effectively with development teams and external clinical experts. Results orientation: Focus on organizational priorities—balancing rigor with pragmatism and avoiding analysis for analysis’ sake. Bias toward solutions and progress: Mindset oriented toward finding solutions, offering alternatives, and maintaining momentum. MA Pay Range $210,000—$252,000 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.