Director, Business Strategy & Operations - Portfolio Strategy

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook. Role Summary: The Director, Strategy & Business Operations is a strategic and operational partner to Dyne’s leadership, playing a central role in enabling effective Executive Committee (EC) and Board decision-making. This leader drives the end-to-end process for EC and Board submissions; synthesizes complex, cross-functional insights into decision-ready narratives; and leads high-priority, cross-enterprise initiatives tied to corporate strategy and operational excellence. Reporting into the SVP, Portfolio Strategy & Operations, the ideal candidate is proactive, highly organized, analytically strong, and thrives in a fast-paced, highly visible environment. They combine executive presence with rigorous analysis, clear storytelling, and an ability to orchestrate alignment and execution across R&D, Manufacturing, Commercial, Finance, and G&A teams. This role is based in Waltham, MA without the possibility of being a remote role. Primary Responsibilities Executive & Board Support Partner closely with executive leadership to plan, coordinate, and manage EC and Board agendas and operating rhythms Lead the development and refinement of EC/Board materials (presentations, dashboards, briefing documents, pre-reads) that are clear, concise, and decision-oriented Ensure leadership materials consistently highlight tradeoffs, risks, scenarios, dependencies, and recommendations Collaborate with HR and other stakeholders on leadership meeting design, cadence, and execution Prepare high-quality briefing materials, presentations, and reports for the CEO and executive team Analytics, Insights & Enterprise Performance Synthesize complex, cross-functional data into executive-level insights, visualizations, and storylines that enable strategic choices and accountability Develop integrated views of performance, progress, risks, and dependencies using data from multiple functions; ensure consistency, accuracy, and relevance Elevate the use of analytics in EC/Board discussions by framing metrics in context (benchmarks, trends, thresholds) and proposing clear actions Strategic Initiatives & Cross-Functional Leadership Lead enterprise-wide, high-priority initiatives that advance corporate strategy and operational priorities Establish project plans, milestones, owners, and success metrics; drive execution and accountability across teams Use data and insights to track progress, identify risks, and recommend course corrections; escalate issues with solutions Lead special initiatives requiring senior leadership engagement and cross-functional coordination Process Excellence & Operating Rhythm Optimization Own and continuously improve the end-to-end process for EC and Board submissions (timelines, templates, standards, content expectations) Drive consistency and quality across leadership materials, including analytical rigor, visual clarity, and narrative coherence Identify and implement opportunities to streamline decision processes, operating rhythms, and cross-functional workflows to enhance organizational effectiveness Stakeholder Engagement & Executive Communications Serve as a trusted liaison between executive leadership and functional teams to ensure alignment, transparency, and timely decision-making Foster strong relationships with internal stakeholders and Board members Draft and refine executive-level presentations and correspondence; support leaders with data-backed storytelling for leadership forums and internal communications Qualifications Bachelor’s degree required; advanced degree (MBA, MS) preferred or equivalent practical experience 10+ years of relevant experience in Strategy & Operations, Corporate Strategy, Management Consulting, PMO/Transformation, or related roles; experience supporting executive/Board governance strongly preferred Demonstrated ability to translate complex, cross-functional data into executive-ready insights, scenarios, and recommendations; strong quantitative and qualitative problem-solving skills Exceptional written and verbal communication skills with a track record of producing concise, compelling leadership materials Proven ability to lead enterprise initiatives, influence without authority, and drive accountability across diverse teams Experience designing and improving operating rhythms, governance processes, and submission standards Advanced proficiency with Microsoft PowerPoint and Excel. Familiarity with dashboarding/visualization tools (e.g., Power BI, Tableau) is a plus MA Pay Range $196,000—$240,000 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.