Associate Director, Inflammation Biology

About Apogee Therapeutics Founded in 2022, Apogee Therapeutics, Inc. (Ticker: APGE) is a well-funded, Nasdaq listed company that offers the opportunity to work in a fast-paced, highly dynamic environment. At Apogee, you can actively contribute to shaping the company culture, take on various roles and responsibilities, and grow professionally. Apogee Therapeutics is a clinical-stage biotechnology company advancing novel biologics with potential for differentiated efficacy and dosing in the largest I&I markets, Apogee’s antibody programs are designed to overcome limitations of existing therapies by targeting well-established mechanisms of action and incorporating advanced antibody engineering to optimize half-life and other properties. Zumilokibart (APG777), the company’s most advanced program, is being initially developed for the treatment of atopic dermatitis (AD), which is the largest and one of the least penetrated I&I markets, as well as asthma. With four validated targets in its portfolio, Apogee is seeking to achieve best-in-class efficacy and dosing through monotherapies and combinations of its novel antibodies. Based on a broad pipeline and depth of leadership and expertise, the company believes it can deliver value and meaningful benefit to patients underserved by today’s standard of care. We are a fast-paced company committed to building an exceptional culture, founded on our C.O.R.E. values: Caring, Original, Resilient and Egoless and a commitment to refusing to stop at “good enough”. If this sounds like you, keep reading! Role Summary The Department of Research and Translational Medicine is seeking an Associate Director, Biology. Reporting to the Director of I&I Biology, this individual will lead and mentor a team of scientists in the Research and Translational Medicine department, providing scientific leadership for studies defining antibody mechanisms of action (MOA) and target biology. Key Responsibilities Apply deep expertise in biology and pharmacology to provide strategic scientific vision and guide therapeutic I&I biology research across atopic dermatitis, allergic asthma, EoE, and other I&I indications. Design, develop, and oversee disease-relevant and complex in vitro and ex vivo models using multiple primary human cell types to evaluate the mechanism of action of Apogee antibodies and target biology. Contribute to authoring and reviewing regulatory submissions and publications. Manage and coordinate projects (in-house & CRO) to ensure adherence to timelines and goals. Establish and promote laboratory best practices. Analyze and interpret complex data from studies to inform on program decisions and effectively communicate outcomes and recommendations to the research group and senior leaders. Collaborate with scientists across functions to generate high-quality data supporting programs from discovery through development. Ideal Candidate Ph.D. degree and a minimum of 8 years of scientific/technical experience. Broad understanding of I&I disease biology (atopic dermatitis, asthma, and EoE) and underlying disease mechanisms is required and familiarity with inflammatory cytokine/chemokine networks is strongly preferred. Hands-on expertise developing and validating complex in vitro and ex vivo functional models using disease relevant cell types Proficiency with analysis of large, cross-platform data sets and assay platforms such as ELISA/MSD, flow cytometry, and cytokine/mediator release assays to characterize and advance therapeutic antibodies and target biology. Ability to manage multiple projects with competing timelines and shifting priorities simultaneously. CRO management experience including evaluation of new CROs is desired. Experience managing and developing junior scientists. BEHAVIORAL COMPETENCIES Successfully exhibit Apogee’s C.O.R.E. values: Caring, Original, Resilient and Egoless Skilled in verbal and written communication in formal and informal settings Self-driven, team-oriented mindset OTHER REQUIREMENTS Ability and willingness to travel 6 times per year for All Hands meetings, team offsite meetings, and conferences Ability to work onsite in the Apogee lab located in Boston, MA four days per week The anticipated salary range for candidates for this role will be $185,000 – $205,000 / year. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography. What We Offer A great culture, grounded in our C.O.R.E. values: Caring, Original, Resilient and Egoless Opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture and company, wear multiple hats, and learn quickly Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits We provide competitive time off, including three weeks PTO, two one-week company-wide shutdowns a year and dedicated paid sick leave Commitment to growing you professionally and providing access to resources to further your development Apogee offers regular all team, in-person meetings to build relationships and problem solve E-Verify Participation: As part of the I9 verification of authorization to work in the US, Apogee participates in E-Verify. To learn more about E-Verify please review this poster. Apogee Therapeutics is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law. To review our privacy policy, click here It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.