Analytical Development Scientist (HPLC)

Work Schedule Standard (Mon-Fri) Environmental Conditions Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.) Job Description Do you have a passion for innovative ideas and groundbreaking discoveries? With over $1 billion invested annually in R&D, at Thermo Fisher Scientific you’ll help solve some of the world’s toughest challenges, from giving cancer patients hope, ensuring safe drinking water and helping law enforcement tackle cases through forensics. We empower our teams to put science into meaningful action and give our R&D colleagues the autonomy, resources, and tools they need to take science a step beyond. Location: On-site Bedford, MA. Relocation assistance is NOT provided.  Must be legally authorized to work in the United States without sponsorship. Must be able to pass a comprehensive background check, which includes a drug screening. Discover Impactful Work: We are seeking an innovative and highly motivated Analytical Development Scientist to join our R&D organization. In this role, you will contribute to the development and commercialization of next-generation analytical technologies with a primary focus on HPLC products and processes supporting critical to quality attributes in the biotechnology and biopharmaceutical industries. You will work in a collaborative, cross-functional environment to develop robust products, characterize product performance, and accelerate new product introductions that address critical customer needs. Experience or familiarity with analytical chromatography product development is highly desirable. Key Responsibilities: Develop, optimize, and apply analytical HPLC methods to characterize product performance and support new product development. Design and execute experiments to evaluate product attributes relevant to regulated bioprocessing, biologics development, and drug-quality monitoring. Develop analytical strategies to assess critical-to-quality attributes, including purity, aggregation, charge variants, identity, concentration, or other relevant product and process attributes. Generate, analyze, and interpret complex analytical datasets to guide technical decisions, product requirements, and development strategy. Evaluate HPLC product performance across relevant use conditions, sample types, workflows, and customer applications. Support product development activities, including feasibility studies, prototype evaluation, design verification, process optimization, technology transfer, and commercialization. Collaborate closely with Product Management, Applications, Manufacturing, Quality, Regulatory, Commercial, and other R&D teams throughout the product lifecycle. Support method transfer, manufacturing validation, and new product introduction activities through robust experimentation and clear documentation. Author technical reports, protocols, SOPs, test methods, presentations, and other scientific documentation. Identify technical risks, troubleshoot analytical challenges, and adapt experiments based on emerging data. Contribute to innovation initiatives by identifying new applications, technologies, customer needs, and product opportunities. Present technical findings and recommendations to internal stakeholders and, when appropriate, external customers. How You Will Get Here: Minimum Qualifications Ph.D. or M.S. with 3+ years of experience in Analytical Chemistry, Biochemistry, Chemical Engineering, Biotechnology, Pharmaceutical Sciences, or a related scientific field preferred; Bachelor's with 5+ years of experience in Analytical Chemistry, Biochemistry, Chemical Engineering, Biotechnology, Pharmaceutical Sciences, or a related scientific field acceptable. Hands-on experience with analytical chromatography systems, preferably HPLC or UHPLC. Strong understanding of analytical chromatography principles, method development, method optimization, and data interpretation. Experience developing or applying analytical methods used to characterize biological molecules, biopharmaceutical products, or process-related attributes. Experience designing experiments, analyzing analytical data, troubleshooting methods, and drawing technically sound conclusions. Demonstrated ability to work effectively in cross-functional technical teams. Strong technical writing, documentation, and communication skills. Preferred Qualifications Experience in a regulated, GMP-adjacent, quality-control, analytical development, process development, or biopharmaceutical laboratory environment. Familiarity with analytical methods used to monitor critical-to-quality attributes in biologics or bioprocessing workflows. Experience with one or more analytical characterization techniques such as SEC, ion exchange chromatography, reversed-phase chromatography, HIC, affinity chromatography, ELISA, IC, DLS, UV-Vis, CE, or mass spectrometry. Familiarity with analytical method lifecycle concepts, including method qualification, validation, transfer, robustness, precision, accuracy, specificity, and system suitability. Knowledge of FDA, ICH, USP, or other regulatory guidance related to drug quality, analytical methods, or biologics characterization. Experience with downstream purification, bioprocessing, biologics development, chromatography media, chromatography columns, or analytical workflow development. Experience supporting technical transfer, manufacturing validation, product launch, or customer-facing technical activities is a plus, but direct product development experience is not required. Ability to identify issues, troubleshoot experiments, adapt quickly based on data, and seek input when needed. What We’re Looking For: Scientific curiosity and a passion for innovation. Strong analytical, problem-solving, and critical-thinking skills. Ability to manage multiple priorities in a fast-paced R&D environment. Collaborative mindset with strong interpersonal skills. Attention to detail and commitment to high-quality experimental execution. Customer-focused approach to product and method development. Comfort working with ambiguity and translating technical data into practical recommendations. Continuous-improvement mindset and willingness to learn new technologies, applications, and workflows. We offer competitive remuneration, annual incentive plan bonus scheme, healthcare, company 401k, and a range of employee benefits! Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation.  Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate based on race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other legally protected status. We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform critical job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.  Compensation and Benefits The salary range estimated for this position based in Massachusetts is $92,000.00–$135,000.00. This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes: A choice of national medical and dental plans, and a national vision plan, including health incentive programs Employee assistance and family support programs, including commuter benefits and tuition reimbursement At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards